(7/1, Primeau) reports, “Patients with human papillomavirus (HPV)-negative vulvar cancer commonly harbored TP53 mutations, according to results from a whole-exome analysis published in Gynecological Oncology.” Specifically, “sequencing identified integration of viral E7 gene from HPV 16 among 35.3% of samples; the remaining were HPV-negative.” Moreover, “the other most common nonsynonymous mutations occurred in some cancer-related genes that were novel to vulvar cancer, and included NBPF1 (20.6%), MACF1 (14.7%), DOCK2 (11.8%), and MAP2 (11.8%).
